Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival
Brückner L, Xu R, Tang J, Gnanasekar A, Herrmann A, Tsz-Lo Wong I, Zhang S, Tu F, Pilon M, Kukalev A, Pardon K, Sidorova O, Atta J, Yu Q, Montouri G, Pradella D, Ilić M, Suina K, Novais-Cruz M, Kaltenbach S, Treue D, Giurgiu-Kraljič M, Herzog S, Hollinger A, Wittstruck N, Fernandez M, Wolozyn N, Becker F, Louma V, Yan X, Schmargon R, Dörr J, Gamlin D, Lehmann A, Gürgen D, Richter M, Dubois F, Simeoni F, Pennycook BR, Hamilton A, Lindemann RK, Dawes C, Balmus G, Hero B, Fischer M, Bafna V, Verhaak R, Wahl G, Liu Y, Koche RP, Papathanasiou S, Medema R, Spanjaard […]
Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers
Montuori G, Tu F, Qin D, Schmargon R, Rodriguez-Fos E, Helmsauer K, Hui H, Mandal S, Purshouse K, Fankhänel L, Bosco B, Spanjaard B, Seyboldt H, Grunewald L, Schmitt M, Gürgen D, Buck V, Rosenfeldt M, Dubois FPB, Schallenberg S, Lehmann A, Theißen J, Taschner-Mandl S, Koch A, Hundsdoerfer P, Künkele A, Eggert A, Fischer […]
Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer
Bei Y, Bramé L, Kirchner M, Fritsche-Guenther R, Kunz S, Bhattacharya A, Rusu M, Gürgen D, Dubios FPB, Köppke JKC, Proba J, Wittstruck N, Sidorova OA, Chamorro González R, Dorado Garcia H, Brückner L, Xu R, Giurgiu M, Rodriguez-Fos E, Yu Q, Spanjaard B, Koche RP, Schmitt CA, Schulte JH, Eggert A, Haase K, Kirwan […]
Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil
Giurgiu M, Wittstruck N, Rodriguez-Fos E, Chamorro González R, Brückner L, Krienelke-Szymansky A, Helmsauer K, Hartebrodt A, Euskirchen P, Koche RP, Haase K, Reinert K, Henssen AG Genome Research (2024), Vol. 34 Issue 9, 1355-1364 https://genome.cshlp.org/content/34/9/1355
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells
Chamorro González R, Conrad T, Stöber MC, Xu R, Giurgiu M, Rodriguez-Fos M, Kasack K, Brückner L, van Leen E, Helmsauer K, Dorado Garcia H, Stefanova ME, Hung KL, Bei Y, Schmelz K, Lodrini M, Mundlos S, Chang HY, Deubzer HE, Sauer S, Eggert A, Schulte JH, Schwarz RF, Haase K, Koche RP, Henssen AG […]