Method development
ecDNA is small and heavily rearranged, and existing methods are not sufficient to characterize it. We have therefore developed our own: scEC&T-seq, an experimental and computational technique that profiles...
ecDNA is small and heavily rearranged, and existing methods are not sufficient to characterize it. We have therefore developed our own: scEC&T-seq, an experimental and computational technique that profiles...
It is remarkable that cancer cells can maintain and transcribe ecDNA, which is non-chromosomal, circular and does not have centromeres. We hypothesize that specific processes are necessary for ecDNA...
ecDNA functions as an evolutionary hotspot, allowing cancers to escape therapy after an initially promising response. We have shown that ecDNA in neuroblastoma is a major source of somatic...
In recent years, it has become apparent that extrachromosomal DNA (ecDNA) is a vehicle for oncogene amplification in most cancers and is associated with worse disease prognosis. What is...